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Without Gla on the amino termini of these factors, they no longer bind stably to the blood vessel endothelium and cannot activate clotting to allow formation of a clot during tissue injury

J Clin Invest (1991) 88:92133.10.1172/JCI115395 117 LenkeiZPalkovitsMCorvolPLlorens-CortesC

Research shows levels typically decrease by 10-15% per decade after age 20

Research using synthetic sponge implantation modelsa standard method for assessing angiogenesisshows TB-500 significantly increases vessel density and organization compared to controls

Angiogenesis: In addition, scientists examine its role in blood vessel formation using endothelial cells